Methyl L-prolinate hydrochloride
- CasNo:2133-40-6
Product Description
Cost-effective and customizable Methyl L-prolinate hydrochloride 2133-40-6 supplier
- Molecular Formula: C6H12ClNO2
- Molecular Weight: 165.62
- Appearance/Colour: crystalline
- Vapor Pressure: 0.135mmHg at 25°C
- Melting Point: 69-71 °C(lit.)
- Refractive Index: -31.5 ° (C=1, H2O)
- Boiling Point: 169.9 °C at 760 mmHg
- Flash Point: 56.5 °C
- PSA： 38.33000
- Density: 1.055 g/cm3
- LogP: 1.04220
Methyl L-prolinate hydrochloride(Cas 2133-40-6) Usage
InChI:InChI=1/C6H11NO2.ClH/c1-9-6(8)5-3-2-4-7-5;/h5,7H,2-4H2,1H3;1H
2133-40-6 Relevant articles
Conjugates of 1′-aminoferrocene-1-carboxylic acid and proline: Synthesis, conformational analysis and biological evaluation
Kovacevic, Monika,Molcanov, Kresimir,Radosevic, Kristina,Srcek, Visnja Gaurina,Roca, Suncica,Cace, Alan,Barisic, Lidija
, p. 12852 - 12880 (2014)
Our previous studies showed that alterat...
Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity
Xie, Sida,Savchenko, Andrei I.,Kerscher, Marion,Grange, Rebecca L.,Krenske, Elizabeth H.,Harmer, Jeffrey R.,Bauer, Michelle J.,Broit, Natasa,Watters, Dianne J.,Boyle, Glen M.,Bernhardt, Paul V.,Parsons, Peter G.,Comba, Peter,Gahan, Lawrence R.,Williams, Craig M.
, p. 1465 - 1476 (2018)
Cyclic peptides, especially those produc...
A dansyl-appended N-heterocycle for Cu2+ and S2? recognition via a displacement mode
Wang, Xu,Xia, Peng,Huang, Xiaohuan
, p. 98 - 104 (2019)
A novel L-proline based heterocycle 3 of...
Synthesis and vibrational spectroscopic investigation of methyl l-prolinate hydrochloride: A computational insight
Balachandran,Boobalan,Amaladasan,Velmathi
, p. 676 - 689 (2014)
In our present work, methyl L-prolinate ...
Captopril analogues as metallo-β-lactamase inhibitors
Yusof, Yusralina,Tan, Daniel T.C.,Arjomandi, Omid Khalili,Schenk, Gerhard,McGeary, Ross P.
, p. 1589 - 1593 (2016)
A number of captopril analogues were syn...
Exercises in pyrrolidine chemistry: Gram scale synthesis of a Pro-Pro dipeptide mimetic with a polyproline type II helix conformation
Reuter, Cedric,Huy, Peter,Neudoerfl, Joerg-Martin,Kuehne, Ronald,Schmalz, Hans-Guenther
, p. 12037 - 12044 (2011)
A practical and scalable synthesis of a ...
Addition of organolithium reagents to Ahc methyl ester. An approach to new α-amino ketones
Avenoza, Alberto,Busto, Jesús H.,Peregrina, Jesús Manuel
, p. 10167 - 10171 (2002)
We have developed a versatile methodolog...
Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties
Hara, Rintaro Iwata,Saito, Tatsuya,Kogure, Tomoki,Hamamura, Yuka,Uchiyama, Naoki,Nukaga, Yohei,Iwamoto, Naoki,Wada, Takeshi
, p. 7971 - 7983 (2019)
In this paper, we describe the first ste...
Ferulic acid amide derivatives with varying inhibition of amyloid-β oligomerization and fibrillization
Kolaj, Igri,Wang, Yanfei,Ye, Kailin,Meek, Autumn,Liyanage, S. Imindu,Santos, Clarissa,Weaver, Donald F.
supporting information, (2021/07/07)
Alzheimer's disease (AD) is a progressiv...
Generic JAKs inhibitor and application thereof
-
Paragraph 0391-0399, (2021/01/30)
The invention discloses a generic JAKs i...
METHODS OF TREATING PAINFUL DIABETIC PERIPHERAL NEUROPATHY
-
Paragraph 0161-0163, (2021/05/14)
Provided herein are methods of treating ...
METHODS OF TREATING FIBROMYALGIA
-
Paragraph 0267-0270, (2021/10/11)
Provided herein are methods of treating ...
2133-40-6 Process route
-
-
67-56-1
methanol
-
-
1447695-69-3
cycloforskamide
-
-
39994-75-7
L-threonine methyl ester hydrochloride
-
-
6306-52-1
L-valine methylester hydrochloride
-
-
60667-85-8
D-allo-isoleucine methyl ester hydrochloride
-
-
18598-74-8
methyl L-isoleucinate hydrochloride
-
-
18598-63-5
L-cysteine methyl ester hydrochloride
-
-
2133-40-6
D-proline methyl ester hydrochloride
| Conditions | Yield |
|---|---|
|
cycloforskamide;
With
hydrogenchloride; water;
at 110 ℃;
for 24h;
methanol;
With
hydrogenchloride;
at 100 ℃;
for 0.5h;
|
-
-
67-56-1
methanol
-
-
147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L -proline
-
-
2133-40-6
L-proline methyl ester monohydrochloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
for 1.5h;
Heating;
|
100%
|
|
With
hydrogenchloride;
for 4h;
Ambient temperature;
|
100%
|
|
With
thionyl chloride;
for 1.5h;
Heating;
|
100%
|
|
With
acetyl chloride;
for 8h;
Heating;
|
100%
|
|
With
thionyl chloride;
at 0 ℃;
for 1h;
|
100%
|
|
With
thionyl chloride;
at 0 - 20 ℃;
|
100%
|
|
With
thionyl chloride;
at 0 ℃;
for 2h;
|
100%
|
|
With
thionyl chloride;
at 20 ℃;
Cooling;
|
100%
|
|
With
thionyl chloride;
for 2h;
Inert atmosphere;
Reflux;
|
100%
|
|
With
thionyl chloride;
for 1h;
Reflux;
|
100%
|
|
With
thionyl chloride;
at 0 - 80 ℃;
for 1.5h;
|
100%
|
|
With
thionyl chloride;
at 0 - 80 ℃;
for 1.5h;
|
100%
|
|
With
thionyl chloride;
at 25 ℃;
for 12h;
|
100%
|
|
With
thionyl chloride;
at 20 ℃;
for 13h;
Cooling with ice;
|
100%
|
|
With
thionyl chloride;
at 0 ℃;
for 1h;
|
100%
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 17h;
Inert atmosphere;
|
100%
|
|
With
thionyl chloride;
1.) 20 deg C, 2 h, 2.) reflux, 90 min;
|
99%
|
|
With
thionyl chloride;
for 22h;
0 deg C to r.t.;
|
99%
|
|
With
thionyl chloride;
at 20 ℃;
for 4h;
|
99%
|
|
With
thionyl chloride;
|
99%
|
|
With
thionyl chloride;
at 0 - 20 ℃;
Inert atmosphere;
|
99%
|
|
With
thionyl chloride;
at 0 ℃;
for 3h;
Reflux;
|
99%
|
|
With
thionyl chloride;
at 95 ℃;
for 4.5h;
Inert atmosphere;
Cooling with ice;
|
99%
|
|
L-proline;
With
pyridine; hydrogenchloride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 0.5h;
methanol;
With
hydrogenchloride;
In
1,2-dichloro-ethane;
at 84 ℃;
for 3h;
Concentration;
Reagent/catalyst;
Solvent;
Reflux;
|
99.6%
|
|
With
thionyl chloride;
at 0 ℃;
for 2.5h;
Reflux;
|
99%
|
|
With
thionyl chloride;
at 65 ℃;
for 2h;
|
99%
|
|
With
thionyl chloride;
at 0 - 70 ℃;
for 16h;
|
99%
|
|
With
thionyl chloride;
at 0 - 70 ℃;
for 16h;
|
99%
|
|
With
thionyl chloride;
at 20 ℃;
for 19h;
|
98%
|
|
With
thionyl chloride;
Cooling with ice;
|
98%
|
|
With
thionyl chloride;
at 20 ℃;
for 27h;
|
97%
|
|
With
thionyl chloride;
at 25 - 30 ℃;
for 0.583333h;
microwave irradiation;
|
96%
|
|
With
thionyl chloride;
Inert atmosphere;
|
96%
|
|
With
acetyl chloride;
for 12h;
Reflux;
|
95%
|
|
With
thionyl chloride;
at 0 - 70 ℃;
for 16h;
|
94%
|
|
With
thionyl chloride;
|
92%
|
|
With
thionyl chloride;
for 2h;
Heating;
|
|
|
With
thionyl chloride;
|
|
|
With
chloro-trimethyl-silane;
|
|
|
With
hydrogenchloride; 3 A molecular sieve;
for 2.5h;
Heating;
|
|
|
With
thionyl chloride;
|
|
|
methanol;
With
acetyl chloride;
for 0.166667h;
L-proline;
at 60 ℃;
for 12h;
|
|
|
With
thionyl chloride;
Heating;
|
|
|
methanol;
With
thionyl chloride;
at 0 ℃;
for 0.5h;
L-proline;
Heating;
|
|
|
With
hydrogenchloride;
at -5 ℃;
for 3.5h;
|
149 g
|
|
With
hydrogenchloride;
for 1.5h;
|
|
|
With
thionyl chloride;
for 1h;
Heating;
|
|
|
With
thionyl chloride;
at 0 ℃;
Reflux;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 1h;
Heating / reflux;
|
|
|
With
thionyl chloride;
for 2h;
Reflux;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 0 ℃;
Reflux;
|
|
|
With
thionyl chloride;
In
methanol;
at 20 ℃;
for 19.5h;
Cooling with ice;
|
|
|
With
thionyl chloride;
In
methanol;
at -30 ℃;
for 1h;
Reflux;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 6h;
|
|
|
With
thionyl chloride;
at 60 - 70 ℃;
|
|
|
With
thionyl chloride;
at 55 ℃;
for 6h;
|
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 4h;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 3h;
Inert atmosphere;
Reflux;
|
|
|
With
hydrogenchloride;
at 100 ℃;
for 0.5h;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 12h;
Reflux;
|
143.9 g
|
|
With
thionyl chloride;
at 0 ℃;
Temperature;
Time;
Reflux;
|
143.9 g
|
|
With
hydrogenchloride;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 70 ℃;
Reflux;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 4h;
Reflux;
|
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 1h;
Reflux;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 22.5h;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
Large scale;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 5h;
Reflux;
|
|
|
With
thionyl chloride;
Reflux;
Large scale;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 12h;
|
|
|
With
thionyl chloride;
at 20 ℃;
|
|
|
With
hydrogenchloride;
at 0 ℃;
for 2h;
Time;
|
|
|
With
thionyl chloride;
Inert atmosphere;
Reflux;
|
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
at 0 - 25 ℃;
Temperature;
Industrial scale;
|
|
|
With
thionyl chloride;
for 1h;
Reflux;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 0 - 75 ℃;
for 16h;
|
|
|
With
thionyl chloride;
at 20 ℃;
for 25h;
Cooling with ice;
|
|
|
With
thionyl chloride;
for 3h;
Reflux;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at -5 ℃;
for 3.5h;
Reflux;
|
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
at 0 ℃;
for 8.33333h;
Reflux;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
Temperature;
Large scale;
|
|
|
With
thionyl chloride;
for 3h;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 15h;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 3h;
|
|
|
With
thionyl chloride;
Cooling with ice;
Reflux;
|
|
|
With
thionyl chloride;
at 20 ℃;
for 24h;
|
|
|
L-proline;
With
chloro-trimethyl-silane;
at 20 ℃;
for 0.333333h;
methanol;
at 20 ℃;
for 24h;
|
|
|
With
thionyl chloride;
at 5 - 20 ℃;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 80 ℃;
|
|
|
With
thionyl chloride;
at 55 ℃;
for 4h;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 16h;
|
|
|
With
thionyl chloride;
at -10 - 20 ℃;
for 0.6h;
|
2133-40-6 Upstream products
-
67-56-1
methanol
-
147-85-3
L-proline
-
147-85-3
L -proline
-
59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester
2133-40-6 Downstream products
-
83549-85-3
1-(N ,O -bis-benzyloxycarbonyl-L-tyrosyl)-L-proline-methyl ester
-
61057-44-1
L-Leu-D-Phe-L-Pro-OMe
-
94313-15-2
1-(4-phenylazo-benzoyl)-L-proline-methyl ester
-
82938-91-8
N-(N-phenylacetyl-β-alanyl)-L-proline methyl ester