Estramustine
- CasNo:2998-57-4
Product Description
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1.What is the Estramustine ?
Estramustine phosphate sodium (Emcyt) is a hybrid structure combining estradiol and a nitrogen mustard in a single molecule. The drug has been approved for use in prostatic carcinomas and will produce clinical remissions in one-third of patients who have failed to respond to previous estrogen therapy. The mechanism of action of estramustine is not well defined, but it does not appear to require either alkylation of DNA or the presence of estrogen receptors in tumor cells. Nonetheless, the toxicities of the drug are similar to those of estrogen therapy: breast tenderness and enlargement (gynecomastia), fluid retention, mild nausea, and an increased risk of thrombophlebitis and pulmonary embolism.The drug is not myelosuppressive.
Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate] is used treatment of breast cancer. Also used in the treatment of prostate cancer.
-
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2998-56-3
N,N-bis-(2-chloroethyl)carbamoyl chloride
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-
50-28-2
estradiol
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2998-57-4
estramustine
| Conditions | Yield |
|---|---|
|
With
dmap; triethylamine;
In
dichloromethane;
at 40 ℃;
for 4.5h;
|
94.1%
|
|
estradiol;
With
tetra-(n-butyl)ammonium iodide; sodium hydroxide;
In
dichloromethane;
at 20 ℃;
for 1h;
N,N-bis-(2-chloroethyl)carbamoyl chloride;
In
dichloromethane;
for 1h;
|
83%
|
|
estradiol;
With
tetra-(n-butyl)ammonium iodide; sodium hydroxide;
In
dichloromethane; water;
at 20 ℃;
for 1h;
N,N-bis-(2-chloroethyl)carbamoyl chloride;
In
dichloromethane; water;
for 1h;
|
83%
|
|
estradiol;
With
tetrabutylammomium bromide; sodium hydroxide;
In
chloroform; water;
at 20 ℃;
for 0.5h;
Inert atmosphere;
N,N-bis-(2-chloroethyl)carbamoyl chloride;
In
chloroform; water;
at 20 ℃;
for 0.5h;
Inert atmosphere;
|
76%
|
|
Multistep reaction;
(i) NaOEt, EtOH, (ii) /BRN= 1765484/, toluene;
|
-
-
62899-40-5
Estromustine
-
-
2998-57-4
estramustine
| Conditions | Yield |
|---|---|
|
With
hydrogen;
nickel;
|
2.What is the CAS number for Estramustine ?
The CAS number of Estramustine is 2998-57-4.
More information of Estramustine 2998-57-4 are:
|
CAS?Number |
2998-57-4 |
|
Density |
1.253 g/cm3 |
|
Melting Point |
104.5 °C |
|
Boiling Point |
565.751 °C at 760 mmHg |
|
Flash Point |
295.956 °C |
|
Vapor Pressure |
1.23E-13mmHg at 25°C |
|
Refractive Index |
1.576 |
|
PSA |
49.77000 |
|
LogP |
5.18200 |
|
Pka |
15.05±0.40(Predicted) |
3.What are another words for Estramustine ?
Synonyms?for?Estramustine 2998-57-4:Estradiol,3-[bis(2-chloroethyl)carbamate] (7CI,8CI);Carbamic acid, bis(2-chloroethyl)-,17b-hydroxyestra-1,3,5(10)-trien-3-ylester (8CI);17b-Estradiol3-[bis(2-chloroethyl)carbamate];Estracty;Estradiol 3-[N,N-bis(2-chloroethyl)carbamate];Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[bis(2-chloroethyl)carbamate];Leo 275;NSC 89201;Ro22-2296/000;(17β)-17-Hydroxyestra-1,3,5(10)-trien-3-yl bis(2-chloroethyl)carbamate;
4.What is the molecular formula of Estramustine?
The chemical formula of ?Estramustine is?C23H31Cl2NO3 which containing 23 Carbon atoms,31 Hydrogen atoms,2 Chlorine atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??Estramustine?is 440.41.
5.What is Estramustine (2998-57-4) used for?
Estramustine is a carbamate ester derived from the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid. It is an antineoplastic agent with a unique mechanism of action, combining the properties of a DNA-binding alkylating agent and an estrogen receptor binder.
InChI:InChI=1/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3/t18-,19-,20+,21+,23+/m1/s1
Relevant articles related to Estramustine:
|
Article |
Source |
|
ANTICANCER AGENTS |
- Page/Page column 27; 33, (2021/02/12) |
|
Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group |
Yempala, Thirumal,Babu, Tomer,Karmakar, Subhendu,Nemirovski, Alina,Ishan, Maisaloon,Gandin, Valentina,Gibson, Dan supporting information, p. 18218 - 18223 (2019/11/13) |
6.Buy Estramustine with the best price .
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